NLRP1 and coronary stenosis: NLRP1 and NLRC4 areupregulated in coronary stenosis and contribute to systemic inflammation, whereas NLRP1,rather than NLRP3, drives the pro-inflammatory state in ECs, highlighting its role in AS [ 74– 76] .Advanced atherosclerotic plaques are marked by numerous dead cells, and nuclear dsDNA is acrucial product released from these cells.