SREBF1 and osteoporosis: We observed some trends; for instance, higher levels of SREBF1 expression in the blood may increase the risk of constipation[OR = 1.220, 95%CI(1.099, 1.135), P = 0.0002], additionally, high SREBF1 expression may also increase genetic susceptibility to osteoporosis[OR = 1.250, 95%CI(1.089, 1.434),P = 0.0016] (Fig. 8).