HAVCR2 and nonpapillary renal cell carcinoma: There was a significant difference in median signal intensity depending on the cell lineage (p < 0.0001), TIM-3 detection was generally higher for lymphoid and myeloid cells than for non-immune cells in all ccRCC samples (p = 5.33 × 10–13 and 1.15 × 10–12 respectively), in line with our findings on the scRNAseq datasets (Supp.