Understanding the biological meaning of plasma sTIM-3 will be crucial for TIM-3-targeted therapies: According to the relevant hypotheses, strategies to treat sTIM-3 high patients would be to either block the putative deleterious action of sTIM-3, inhibit ADAMs’ activities, deplete TIM-3 + pro-tumor myeloid cells or restore the function of paralyzed APC. This evidence concerns the gene APC and neoplasm.