NLRP3 and neoplasm: Among the top DEG, the putative pro-tumor markers TREM2 and APOE were found increased in HAVCR2 + ADAM + myeloid cells (Khantakova, Brioschi, et Molgora 2022; Bancaro et al. 2023), while NLRP3 was decreased, which may be linked to decreased APC functionality through inflammasomes (Dixon et al. 2021).