SP1 and neoplasm: Furthermore, miR-22 suppresses tumor proliferation, tumorigenesis, and metastasis by targeting proteins, including Protein Kinase C Inhibitor Protein-1 YWHAZ, cluster of differentiation 147 (CD147), galectin-1 (LGALS1), cyclin A2 (CCNA2), and specificity protein 1 (SP1) [1, 4–7].