Notably, although overexpression of miR-1906 or knockdown of CLIC1 largely phenocopied circAPP knockdown, it was not identical to the level provided by circAPP knockdown in AD microglial polarization, pathology and cognitive function, indicating that other potential targets might be involved in circAPP-mediated regulation of AD microglial polarization and pathology. The gene discussed is CLIC1; the disease is Alzheimer disease.