Furthermore, miR-1906 overexpression attenuated the expression of Iba-1, CD16, TNF-α, pro- and cleaved IL-1β, and promoted the expression of Arg1 and IL-10 in Aβ-treated BV-2 cells and the hippocampus of APP/PS1 mice (Fig. 5H ~ S), suggesting that miR-1906 overexpression modulates microglial M1/M2 polarization in AD. This evidence concerns the gene AIF1 and Alzheimer disease.