APP and Alzheimer disease: The results showed that miR-1906 overexpression promoted Aβ phagocytosis of BV-2 cells, downregulated the expression of Aβ and p-tau, and improved spine density in the hippocampus of APP/PS1 mice (Fig. 5T ~ W), suggesting a role of miR-1906 in the amelioration of Aβ phagocytosis and AD pathology.