APP and Alzheimer disease: Additionally, CLIC1 knockdown caused a decrease in the expression of Iba-1, CD16, TNF-α, pro- and cleaved IL-1β, and an increase in the expression of Arg1 and IL-10 in Aβ-treated BV-2 cells and the hippocampus of APP/PS1 mice (Fig. 3H ~ S), suggesting that CLIC1 knockdown regulates microglial M1/M2 polarization in AD.