APP and Alzheimer disease: The results revealed that CLIC1 knockdown increased Aβ phagocytosis of BV-2 cells, decreased Aβ and p-tau expression, and improved spine density in the hippocampus of APP/PS1 mice (Fig. 3T ~ W), suggesting an ameliorative role of CLIC1 knockdown in Aβ phagocytosis and AD pathology.