Of the 1035 consecutive cases reviewed, 42 (4.1%) were diagnosed with a non-hypermobile EDS (Classical EDS, n = 18; Classical-like EDS, n = 2; Vascular EDS, n = 16; Arthrochalasia EDS, n = 1; Kyphoscoliotic EDS, n = 2; Musculocontractural EDS, n = 1; Periodontal EDS, n = 2), 81 (7.8%) were diagnosed with hEDS, 410 (39.6%) were diagnosed with G-HSD, and 502 (48.5%) were not to meet diagnostic criteria for EDS or G-HSD (i.e. not-EDS/G-HSD). Here, CHST3 is linked to Ehlers-Danlos syndrome, periodontitis type.