Predicting Renal Outcomes in ADPKD (PROPKD) score: The pathogenic variant in ADPKD can predict disease progression, with protein truncating variants in PKD1 linked to early ESKD with a median age 55 compared to missense PKD1 and PKD2 variants with median ages 67 and 79 respectively. Here, PKD1 is linked to autosomal dominant polycystic kidney disease.