PKD2 and autosomal dominant polycystic kidney disease: Predicting Renal Outcomes in ADPKD (PROPKD) score: The pathogenic variant in ADPKD can predict disease progression, with protein truncating variants in PKD1 linked to early ESKD with a median age 55 compared to missense PKD1 and PKD2 variants with median ages 67 and 79 respectively.