CDKN2B and myelodysplastic syndrome: On the contrary, specific genes, involved in hematopoietic differentiation, apoptosis, and cell cycle regulation, such as Cyclin Dependent Kinase Inhibitor 2B (CDKN2B or P15)(Au et al. 2003; Raj et al. 2007), adenosine 5’-Monophosphoramidase (HINT1)(Iwai et al. 2005) and gene sets including P15(Shen et al. 2010), have been detected in hypermethylated mode and silenced, often associated with adverse clinical outcomes in MDS patients.