Long-lasting GLP-1 analogues, including dulaglutide (Trulicity), exenatide (Byetta), liraglutide (Victoza) and semaglutide (Ozempic, Wegovy and Rybelsus), have recently come into the limelight as blockbuster drugs for the treatment of type 2 diabetes and associated obesity as well as lifestyle drugs to reduce body weight in the absence of exercise by increasing satiety and lowering gastric emptying45. Here, GLP1R is linked to Obesity.