Long-lasting GLP-1 analogues, including dulaglutide (Trulicity), exenatide (Byetta), liraglutide (Victoza) and semaglutide (Ozempic, Wegovy and Rybelsus), have recently come into the limelight as blockbuster drugs for the treatment of type 2 diabetes and associated obesity as well as lifestyle drugs to reduce body weight in the absence of exercise by increasing satiety and lowering gastric emptying45. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.