LATS1 and cancer: Considering epithelial, stromal, and immune cell types all associate with ECM remodeling in cancer (Winkler et al, 2020), the strong ECM phenotypes we observed suggested that microenvironment changes driven by Lats1/2 inactivation in luminal cells may initiate a niche allowing for oncogenic transformation of both epithelial cells and stromal cell populations, resulting in basal-like carcinomas.