The TEAD transcription factors are also expressed across many cell populations in our scRNA-seq data, with Tead1 predominantly expressed in the Lats1/2-null epithelium, along with lower levels of Tead2 and Tead4. Treatment of Lats1/2ff; lsl-EYFP; Krt8CreERT2 mice with VT104, a pan-TEAD inhibitor that blocks the palmitoylation pocket of TEADs (Tang et al, 2021), reversed all carcinoma phenotypes, including blocking the development of the tumor-stroma niche. This evidence concerns the gene TEAD4 and neoplasm.