Studies have shown that the intercellular junction protein vinculin can promote the development of renal fibrosis by regulating the EMT process of renal tubular epithelial cells, and the mechanism involves the activation of p38 signaling pathway induced by acetic acid58, the action of angiotensin II (Ang II)64, and T cell death-associated genes 51 (TDAG51) on vinculin regulation65and other levels. The gene discussed is PHLDA1; the disease is renal fibrosis.