It has been found that the induction of aptamers and cytoskeletal proteins such as vinculin in podocytes is inhibited under diabetic conditions, the levels of focal adhesion components are decreased in DN, however, phosphorylated vinculin is upregulated under hyperglycemic conditions, and podocyte adhesion to the basement membrane is impaired. The gene discussed is DNM2; the disease is liver dysplastic nodule.