The network that is highly Dex-dependent includes several coregulators, e.g. CREBBP, NCOR1, TBL1XR1 and ARID1A, and B cell lineage TFs, e.g. RUNX1, EBP1, ERG, IKZF1, LEF1, PAX5, TCF3, TCF4 and TCF12, whose genes are frequently disorganized in B-ALL [45]. Here, CREBBP is linked to precursor B-cell acute lymphoblastic leukemia.