TARDBP and Spinocerebellar ataxia type 3: We illustrate the resulting AlphaFold-Metainference approach for a set of well-studied highly disordered proteins30  as well as for proteins that include both ordered and disordered domains, including TAR DNA-binding protein 43 (TDP-43), which is associated in amytrophic lateral sclerosis (ALS)31, ataxin-3, which is linked with Machado–Joseph disease (also known as spinocerebellar ataxia type 3)32, and the human prion protein33, which causes Creutzfeldt–Jakob disease and related prion diseases34.