By comparing the cardiovascular hemodynamics and the outcome of acute myocardial infarction in RBC- and EC-specific eNOS−/− mice, we recently demonstrated that eNOS present in RBCs regulates blood pressure and the levels of circulating NO metabolites and is cardioprotective (Leo et al, 2021; Cortese-Krott et al, 2022). Here, NOS3 is linked to myocardial infarction.