NOS3 and endothelial dysfunction: Thus, increased arginase activity in the vessel wall was proposed to limit the bioavailability of l-arginine for eNOS and therefore decrease NO production, resulting in endothelial dysfunction and hypertension (Zhang et al, 2001; Toque et al, 2013; Caldwell et al, 2018; Mahdi et al, 2020a; Li et al, 2022c).