For this C57BL/6 WT, Gal-9 KO, Gal-3 KO and combined Gal-9 and Gal-3 KO mice were subjected to Dextran Sodium Sulfate (DSS) induced colitis causing severe intestinal inflammation driven by epithelial cell damage (Fig. 1A). The gene discussed is LGALS3; the disease is colitis.