Excessive infiltration of macrophages into inflamed mucosa marks a characteristic feature of IBD [28], [29], [30].Studies with peritoneal macrophages indicate that macrophages which lack Gal-3 display reduced phagocytic capacity of apoptotic cells, compared to wildtype (WT) macrophages, resulting in delayed inflammatory resolution [10]. This evidence concerns the gene LGALS3 and inflammatory bowel disease.