We validated the expression trends of 26 NRGs in the GSE64634 dataset, identifying PHACTR1, RHOH, EMR3, SLC16A7, TMEM71, and CR1 as consistently downregulated in tumor tissues across both GSE64634 and GSE53819 datasets (Fig. 2A‒B). The gene discussed is TMEM71; the disease is neoplasm.