Although no studies have directly linked TMEM71 to NLRP3, other members of the TMEM family, have been shown to regulate pyroptosis by modulating intracellular calcium levels, promoting inflammasome formation, and activating caspase-1.13, 14 TMEM71 may participate in the activation of the inflammasome through similar mechanisms, thus playing a role in NPC progression. The gene discussed is TMEM71; the disease is nasopharyngeal carcinoma.