Also, GBE is involved in the activation of the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, affecting NFκB, mTOR, Nrf-2, and Wnt/β-catenin signalling pathways [40], which are implicated in the pathogenesis of glaucoma [43–45]. The gene discussed is NFKB1; the disease is glaucoma.