TP53 and central nervous system cancer: KEGG pathway analysis revealed that these proteins were enriched in various cancers including PCa (such as small cell lung cancer, bladder cancer, glioma, pancreatic cancer and melanoma), biological processes (such as cell cycle, cellular senescence and focal adhesion) and molecular signals (such as p53, PI3K/Akt and FoxO signaling pathways) (Fig 6B).