In order to gain information regarding numbers of individuals with NCFBE who may be eligible for the ‘main’ study (see below), patients at Emory followed with bronchiectasis (who do not exhibit clinical manifestations adequate for a diagnosis of cystic fibrosis) will be asked to consider participating in a ‘lead in’ study that will determine CFTR genotype and sweat chloride level for each subject. Here, CFTR is linked to cystic fibrosis.