In patients with DLBCL, the expression rates of NOTCH1 and Hairy and enhancer of split 1 (Hes1) are significantly elevated compared to the control group, with NOTCH1 expression closely linked to B symptoms, Ann Arbor staging, lymphocyte count, and lactate dehydrogenase levels [1]. This evidence concerns the gene HES1 and diffuse large B-cell lymphoma.