Another research revealed shared transcriptional features between in vitro activated plasmacytoid dendritic cells and those present in lupus nephritis lesions including SLC7A5, SLC3A2, SLC7A11 along with ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), where SLC3A2 was implicated in the immune response in lupus nephritis [78]. The gene discussed is SLC7A11; the disease is lupus nephritis.