Importantly, our results here also suggest that agents that activate CHOP expression either by activating the unfolded protein response/ER stress pathway or the ISR pathway may be useful for “lytic induction” therapy of EBV+ epithelial tumors, in which the goal is to kill latently infected-EBV positive tumor cells by inducing the lytic form of viral infection. The gene discussed is DDIT3; the disease is viral infectious disease.