KCNJ10 and major depressive disorder: Indeed, a loss of function or reduced expression of Kir4.1 has been associated with neurode-generative disorders,36 such as hippocampal sclerosis,37 animal models of Huntington’s disease,38,39 Rett syndrome,40 fragile X syndrome,41 or epilepsy,42,43 whereas Kir4.1 overexpression has been related to depression behavior44 and appears as a compensatory mechanism under pilocarpine-induced seizures.45