The phenomenon of CSD8 is associated with a number of neurological disorders including migraine with aura, traumatic brain injury, stroke, glioblastoma, and epilepsy.74 Given its importance, a recent resurgence in the new approaches and tools aimed at its exploration has been reported.63,65 That the sparsely distributed Kir4.1* astrocytes can locally attenuate the spreading waves of high extracellular K+ upon CSD initiation (Figures 5G–5L) brings about two conclusions. This evidence concerns the gene KCNJ10 and nervous system disorder.