IL6 and cancer: Stress was associated with elevated levels of several chemokines known to promote immune cell recruitment and cancer cell invasion (CCL4: β, 0.03 [95% CI, 0.0002-0.05], P = .048; CCL19: β, 0.03 [95% CI, 0.01-0.06], P = .02; and CCL20: β, 0.04 [95% CI, 0.01-0.06], P = .005), as well as proangiogenic factors (TIE2: β, 0.04 [95% CI, 0.01-0.07]; P = .009 and ANGPT2: β, 0.03 [95% CI, 0.005-0.06]; P = .02) and the proinflammatory cytokine IL-6 (β, 0.04 [95% CI, 0.01-0.07]; P = .006) (Figure 1A).