KLK3 and prostate carcinoma: While healthier men with a high baseline PSA may benefit from continued screening, they are also at higher risk for the harms of prostate biopsy, and many prostate cancers in this population may still be overdiagnosed.10 We also found that race and ethnicity had a very limited association with long-term PCSM risk, though slightly larger differences were found in mPCa risk.