Although we have demonstrated the necessity of the APC in social novelty, investigating its sufficiency is not feasible due to the significant promotion of seizure generation and propagation by chemogenetic or optogenetic activation of APC pyramidal neurons.[28] Decreased activity of the piriform cortex has been reported in autism spectrum disorder (ASD) patients.[29] Given the role of the APC in social novelty, it is necessary to examine how the APC activity is altered and whether APC activation affects social behavior in ASD mouse models. Here, APC is linked to autism spectrum disorder.