A diverse selection of biomarkers including acute‐phase proteins [CRP and Pentraxin-3(PTX3)], inflammatory mediators (TNF-α, IL-6, IL-8, IL-4, IL-10, IL-2Rα/CD25) as well as DAMPs (cfDNA), which are associated with an unfavorable prognosis and depict signaling pathways as potential therapeutic targets in sepsis, were investigated [14–22]. The gene discussed is IL6; the disease is Sepsis.