SNHG4 and central nervous system cancer: To verify the biological roles of SNHG4 in glioma cells, we transfected small interference RNA (siRNAs-SNHG4) to knockdown the expression of SNHG4 in Ln229 and U251 cells, and over-expression plasmids (pcDNA3.1, pcDNA3.1-SNHG4) to upregulate SNHG4 expression.