Genetically proxied PDE5 inhibition was associated with higher odds of Alzheimer’s disease (OR 1.09, 95% CI 1.07–1.11, p < 0.001) and Lewy body dementia (OR 1.32, 95% CI 1.23–1.41, p < 0.001) per SD lower in diastolic blood pressure (Fig. 2). The gene discussed is PDE5A; the disease is Alzheimer disease.