RGZ is beneficial for lowering blood pressure (BP) by modulating the renin‒angiotensin II system.[31] Notably, neither plCSA‐NPs nor plCSA‐RNPs ameliorated RUPP‐induced gestational hypertension, elevation of serum soluble FMS‐like tyrosine kinase‐1 (sFlt1), or morphological changes in the kidney (Figure S7L–N, Supporting Information). Here, REN is linked to preeclampsia.