In mice, especially in C57BL/6J mice, at least 3 months are needed for HFD to induce diabetes.[30] Insulin resistance, inflammation, kidney injury, and cardiac remodeling occur 6–8 months after eating a HFD.[31] Our results demonstrated that intestinal epithelial cell CCKBR is a promising target in the treatment of TD, the deficiency of which significantly accelerated the progression of Pre‐DM to T2D. The gene discussed is CCKBR; the disease is type 2 diabetes mellitus.