CCKBR and type 2 diabetes mellitus: For individuals with Pre‐DM, lifestyle modification can reduce the risk of DM by 40–70%.[27] Prolonged exposure to unhealthy diets, especially those high in carbohydrates and saturated fats, has been implicated in the pathogenesis of Pre‐DM, which progresses to overt T2D, if left uncontrolled.[29]Villin‐Cckbr−/− mice developed T2D, after 1 month of HFD (60% fat)‐fed, much faster than the control mice (Villin‐Cckbr+/+) that developed T2D after 3–4 months of HFD.