To further assess the potential role of intestinal epithelial cell CCKBR in the progression of T2D, Gastrin‐SiO2 microspheres (Chinese patent number: ZL 2021 1 0223615.0) were designed to activate CCKBR in the intestinal epithelial cells of HFD‐induced diabetic mice. The gene discussed is GAST; the disease is type 2 diabetes mellitus.