CCKBR and cardiovascular disorder: Pre‐DM, a precursor of TDM, has mild hyperglycemia which significantly increases the risk of cardiovascular diseases before the blood glucose level actually reaches the diabetic range.[27, 28] In the current study, Villin‐Cckbr−/− mice developed a Pre‐DM phenotype at 1 month of age, indicating that the effects of Cckbr silencing, rather than environmental factors, contribute to diabetes progression.