The long‐term subcutaneous infusion of gastrin protected against the hypertensive nephropathy induced by unilateral ureteral obstruction, decreased the apoptosis of the cardiomyocytes and improved the myocardial function in mice with myocardial infarction.[32] However, circulating gastrin also induces cell hyper‐proliferation, and leads to cancer, including colorectal cancer.[33] In the current study, we designed Gastrin‐SiO2 microspheres to act specifically and selectively in intestinal epithelial cells preventing the absorption of gastrin into the circulation. This evidence concerns the gene GAST and Ureteral obstruction.