Meanwhile, CAFs enhance pancreatic ductal adenocarcinoma clonogenic (PDAC) growth, and promote CSC self‐renewal and proliferation by producing type I collagen that activates the integrin‐FAK signaling pathway.[47] Herein, we demonstrated that iCAFs highly expressed inflammatory chemokines and cytokines, including IL1B, IL11, IL24, CXCL1, CXCL3, and CXCL8, and are enriched in WNT, VEGF, EGFR, and tumor angiogenesis signaling pathways, which establish a niche that supports the maintenance and invasion of CSCs. This evidence concerns the gene VEGFA and pancreatic ductal adenocarcinoma.