MCAM and gastric cancer: found that activation of cGAS‐STING signaling drive the SLC14A1+ CAF differentiation, which in turn confers stemness to bladder cancer cells via WNT5A paracrine pathway.[26] Our group has demonstrated that CD146+ vascular CAFs could enhance tumorigenesis and stemness of intrahepatic cholangiocarcinoma cells via the IL‐6/IL‐6R axis.[27] Although several studies have explored the mechanisms of GC initiation and progression, the intricate cellular and spatial architecture of the CSC niche driving GC progression requires further investigation.