Integrating scRNA‐seq and spatial transcriptomic analysis, we demonstrated that iCAFs highly interacted with CSCs through AREG‐ERBB2 axis, which has previously been reported to be induced by TGFβ in myofibroblasts to promote PDAC metastasis.[48] Considering that targeting AREG derived from senescent stroma can attenuate cancer resistance and reverse PD‐L1 mediated immunosuppression,[49] a combinational treatment targeting AREG and CSCs may potentially provide an effective approach for treating GC. The gene discussed is CD274; the disease is gastric cancer.