found that activation of cGAS‐STING signaling drive the SLC14A1+ CAF differentiation, which in turn confers stemness to bladder cancer cells via WNT5A paracrine pathway.[26] Our group has demonstrated that CD146+ vascular CAFs could enhance tumorigenesis and stemness of intrahepatic cholangiocarcinoma cells via the IL‐6/IL‐6R axis.[27] Although several studies have explored the mechanisms of GC initiation and progression, the intricate cellular and spatial architecture of the CSC niche driving GC progression requires further investigation. This evidence concerns the gene IL6R and gastric cancer.