The KEGG (Figure 5F) and PROGENy (Figure 5G) analysis of different CAF subtypes unveiled that iCAFs were enriched in the IL6 signal pathway, hypoxia, and tumor growth signals, including EGFR, WNT, MAPK, and TGF‐β, all of which are critical for CSC maintenance.[36] Additionally, our results highlighted the involvement of tumor angiogenesis related signaling pathway VEGF‐VEGFR in both iCAFs and CST1+ mCAFs (Figure 5F), indicating their important roles in promoting tumor invasion and metastasis. Here, CST1 is linked to neoplasm.