This activation drives an inflammatory cascade, amplifying the immune response.[38, 39] Macrophages, as innate immune cells with dynamic phenotypic plasticity, hold an important position in the progression of AP.[40] STING proteins directly influence the generation of IFNs, promoting M1 polarization of macrophages and affecting the recruitment of undifferentiated macrophages.[41, 42, 43] The present study confirms that mt‐DNA released from PACs during AP activates macrophages via the STING pathway, promoting M1 polarization and contributing to an inflammatory storm. This evidence concerns the gene STING1 and alkaline phosphatase measurement.