In a study of 168 cases, the CR rate was 92.9%, with a low recurrence rate of 3.6%, which contrasts with the higher recurrence rate of 12.1% found in the present series of 313 patients.10,21 Prior studies also show lower CR rates in VHL-associated hemangioblastomas than in sporadic cases, contributing to higher recurrence. This evidence concerns the gene VHL and hemangioblastoma.