Dysregulated TLR8 signalinghas been implicated in the pathogenesis of autoimmune diseases, includingsystemic lupus erythematosus (SLE) and rheumatoid arthritis (RA),where persistent TLR8 activation contributes to chronic inflammationand tissue damage.−,  TLR8 has also been recognized to play a significantrole in the regulation of viral infections., This evidence concerns the gene TLR8 and rheumatoid arthritis.