For example, small-molecule TLR8 antagonistshave demonstrated potential for modulating cytokine levels in autoimmunediseases such as SLE and RA., Several TLR7/8 ligands,including small molecules and antibodies, have been identified andare currently in preclinical and clinical trials., Enpatoran (M5049), a synthetic small-molecule TLR7/8 antagonist,is currently being investigated as a potential treatment for SLE. However, selective TLR8 antagonists have yetto be fully explored in clinical studies. The gene discussed is TLR8; the disease is rheumatoid arthritis.