[98] found that exosomes originated from hypoxic glioma cells improved propagation and inhibited apoptosis of glioma cells treated with TMZ, which was inhibited by the miR‐106a‐5p inhibitor TMZ increased PTEN and Bax levels and attenuated p‐Akt levels in glioma cells TMZ increased PTEN and Bax levels and attenuated p‐Akt levels in glioma cells. This evidence concerns the gene PTEN and central nervous system cancer.