[92] adxised that normal human astrocytes (NHA) are transformed into response astrocytes (RAS), that the ratio of O6 methylguanine DNA methyltransferase (MGMT) mRNA to non‐reactive NHA is significantly increased in exosomes (EXO) released from the RAS, and that RAS‐EXO is MGMT passive glioma cells, and a TMZ resisted phenotype are obtained in vitro and in vivo by interpretation of exogenous exosomal MGMT mRNA. Here, MGMT is linked to central nervous system cancer.