The initial impact of cancer‐associated fibroblasts on tumour development depends primarily on the abnormal secretion of various proteins from exosomes, hepatocyte growth factor (HGF), tumour necrosis factor‐α (TNF‐α), interleukin 6 (IL‐6) and transforming growth factor‐β (TGF‐β) are included. The gene discussed is IL6; the disease is cancer.