In CRC with BRAF V600E, 523 (42.6%) had TMB ≥ 35, 382 (31.1%) had TMB ≥ 50, 245 (20%) had TMB ≥ 75, and 149 (12.1%) had TMB ≥ 100. The gene discussed is BRAF; the disease is colorectal carcinoma.