In CRC with KRAS G12A, 74 (23.1%) had TMB ≥ 35, 68 (21.3%) had TMB ≥ 50, 62 (19.4%) had TMB ≥ 75, and 48 (15%) had TMB ≥ 100. The gene discussed is KRAS; the disease is colorectal carcinoma.