Considering both fusion partners and intra‐ and inter‐chromosomal rearrangement, the mean TMB was 55.1 ± 25.5 for NTRK1/3+ CRC (N = 15), and 26.6 ± 21.7 for RET+ CRC (N = 10), which were significantly higher when compared to other RTK+ CRC (p < 0.05) (Table 1). This evidence concerns the gene NTRK1 and colorectal carcinoma.