Nanocarriers using Sia modified amphiphilic egg phosphatidylglycerol structure accumulated at the TAM rich site, enhancing ibrutinib effect and reducing off‐targeting.[57] Meanwhile Sia cyclodextrin carriers achieved complex TME in prostate cancer, delivering siRNA to TAMs, causing reprogramming.[58] Here we show that using glycans to target specific pattern recognition receptors expressed in macrophages such as CD206 and CD169 is a viable immunotherapy that can be used to treat liver diseases such as CRC hepatic metastases or PBC, two completely opposite pathologies. This evidence concerns the gene MRC1 and Familial prostate cancer.