IFNG and autoimmune disease: Aberrant activation of pro‐inflammatory myeloid cells and sustained production of inflammatory cytokines, such as IFN‐γ, play a crucial role in the pathology of PBC.[47, 48] To explore the role of Man in immune cell activation and its potential to repolarize macrophages toward a restorative phenotype in autoimmune diseases, we evaluated the effects of a single administration of Man‐GNPs in ARE Del−/− mice model.