To evaluate the extent to which H-DNA accumulates oxidative damage relative to B-DNA, we first performed an immuno-slot blot assay (Fig. 2A) using a substrate with an H-DNA-forming sequence from the human c-MYC promoter that maps to a translocation breakpoint hotspot in Burkitt lymphoma (Fig. 1B) [42]. Here, MYC is linked to Burkitt lymphoma.