The relationship between the PI3K/AKT signaling axis has demonstrated the essential regulatory role of this pathway in EMT (Grille et al., 2003) and the AKT inhibition induced the expression of E-cadherin and beta-catenin, reduce that of Vimentin, restored their epithelial morphology of oral squamous cell carcinoma (Hong et al., 2009). The gene discussed is CTNNB1; the disease is oral cavity squamous cell carcinoma.