Notably, WNT2B overexpression promoted proliferation, colony formation and the EMT process in NSCLC cells with miR-577 overexpression and under basal conditions (Wang S. et al., 2018) and are directly regulated by the transcription factor PITX2, which was highly overexpressed in our sotorasib resistance model, along with LEF1 gene, that also plays a key role in activating WNT/β-Catenin-mediated pathway and is portrayed in lung adenocarcinoma metastasis (Nguyen et al., 2009). This evidence concerns the gene PITX2 and lung adenocarcinoma.