It was conducted in type 2 diabetes patients > 30 years of age, with an eGFR of 30-<90 ml per minute per 1.73 m2 (CKD), a urinary albumin to creatinine ratio of >300–5,000 mg/g (macroalbuminuria), and already treated with renin-angiotensin system blockade. This evidence concerns the gene ALB and chronic kidney disease.