In our series, we found that culture-negative patients had overall more severe sepsis than culture-positive ones, in terms of: higher inflammatory status, as assessed by increased leukocyte counts and CRP levels; higher levels of procalcitonin; greater tissue hypoperfusion and renal impairment, with higher lactate and creatinine levels; and more rapid and unfortunate evolution, with shorter hospital stays and higher mortality rates (Table 1 and Supplementary Figures S1A–F). This evidence concerns the gene CRP and Sepsis.