Increasing evidence suggests that hydrogen molecules can enhance antioxidant capacity by inhibiting the Nrf-2/HO-1 and NF-κB pathways, thereby contributing therapeutically to wound healing, hypoxia/ischemia injury, and Alzheimer’s disease (Li et al., 2022; Cai et al., 2008; Wang et al., 2011). Here, HMOX1 is linked to early-onset autosomal dominant Alzheimer disease.