Additionally, a combined clinical and epigenetic trial involving 54 NAFLD patients found that phytosome curcumin supplementation (250 mg/day for 8 weeks) reduced promoter methylation of MLH1 and MSH2(Two important mismatch repair proteins), thereby lowering the risk of base pair mismatches in the DNA of NAFLD patients (Hariri et al., 2020). The gene discussed is MLH1; the disease is metabolic dysfunction-associated steatotic liver disease.