MSH2 and metabolic dysfunction-associated steatotic liver disease: Additionally, a combined clinical and epigenetic trial involving 54 NAFLD patients found that phytosome curcumin supplementation (250 mg/day for 8 weeks) reduced promoter methylation of MLH1 and MSH2(Two important mismatch repair proteins), thereby lowering the risk of base pair mismatches in the DNA of NAFLD patients (Hariri et al., 2020).