While BRAF V600E mutations have been observed in multiple types of cancers, such as lung carcinoma and haematological malignancies like hairy cell leukaemia, there is no reports of the simultaneous occurrence of BRAF V600E mutations in both NSCLC and papillary thyroid carcinoma with pleural metastasis. The gene discussed is BRAF; the disease is thyroid gland papillary carcinoma.