On the 33rd day of colitis, under MP influence in the colon, there was also a more pronounced colon shortening, a higher Pathological score, higher proinflammatory cytokine Tnfa mRNA expression, and lower anti-inflammatory cytokine Il10 mRNA, as well as higher activity of the MAPK signaling pathway: higher levels of phosphorylation of Erk1/2, JNK and p38. The gene discussed is TNF; the disease is colitis.