SOHLH1 and Azoospermia: In previous studies, Choi et al. and Nakamura et al. identified a heterozygous mutation (c.346-1G>A) in SOHLH1 in patients with non-obstructive azoospermia, suggesting a link between heterozygous mutations in this gene and the condition (Choi et al., 2010; Nakamura et al., 2017).