There were no significant differences in age, marital status, menstrual status, tumor size, multifocal or multicenter tumors, axillary lymph node metastasis, the number of metastatic lymph nodes, ER, PR, Ki-67 expression, type of breast surgery, or axillary treatment (χ2 test, p > 0.05). This evidence concerns the gene ESR1 and neoplasm.