In order to clarify its regulatory mechanism, we detected the changes in key cell cycle protein of G2/M, and we found decreased levels of Cyclin B1 protein in SHCBP1 knockdown PCa cells (Figure 5A), suggesting that SHCBP1 may regulate G2/M cycle transition by regulating Cyclin B1. This evidence concerns the gene SHCBP1 and posterior cortical atrophy.