GNE and Distal myopathy, Nonaka type: Additionally, GNE myopathy, an adult‐onset disorder caused by recessive mutations in the UDP‐N‐acetylglucosamine‐2‐epimerase/N‐acetylmannosamine‐kinase (GNE) gene, has shown potential for AAV‐delivered GNE gene replacement in cellular and murine models.195, 196